Sir Richard Henry Treisman (born 7 October 1954) One or more of the preceding sentences incorporates text from the royalsociety.org website where: is a British scientist specialising in the

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

of cancer. Treisman is a director of research at the

Francis Crick Institute The Francis Crick Institute (formerly the UK Centre for Medical Research and Innovation) is a biomedical research centre in London, which was established in 2010 and opened in 2016. The institute is a partnership between Cancer Research UK, Impe ...

in London.

Education

Treisman was educated at

Haberdashers' Aske's Boys' School Haberdashers' Boys' School (also known as Haberdashers', Habs, or Habs Boys), until September 2021 known as Haberdashers' Aske's Boys' School, is a public school for pupils age 4 to 18 in Elstree, Hertfordshire, England. The school is a me ...

and

Christ's College, Cambridge Christ's College is a constituent college of the University of Cambridge. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 170 graduate students. The college was founded by William Byngham in 1437 as ...

, where he was awarded a Bachelor of Arts degree in 1977. He completed his postgraduate study at the

Imperial Cancer Research Fund Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

(ICRF) and

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

, where he was awarded a PhD for research on

polyomavirus ''Polyomaviridae'' is a family of viruses whose natural hosts are primarily mammals and birds. As of 2020, there are six recognized genera and 117 species, five of which are unassigned to a genus. 14 species are known to infect humans, while othe ...

transcription and

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

processing supervised by Bob Kamen in 1981.

Career and research

After his PhD, Treisman pursued

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

globin The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myo ...

gene expression and

thalassemia Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result ...

genes with

Tom Maniatis Tom Maniatis (born May 8, 1943), is an American professor of molecular and cellular biology. He is a professor at Columbia University, and serves as the Scientific Director and CEO of the New York Genome Center. Education Maniatis received B.A ...

. In 1984, he joined the Medical Research Council (MRC)

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

(LMB) at the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

, where he started working on how

growth factor A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regu ...

s control transcription. Initially focusing on the Fos gene, he identified the

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...

Serum response factor Serum response factor, also known as SRF, is a transcription factor protein. Function Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum ...

(SRF) and cloned its gene, before returning to London in 1988. He showed that the TCF family of SRF

cofactors Cofactor may also refer to: * Cofactor (biochemistry), a substance that needs to be present in addition to an enzyme for a certain reaction to be catalysed * A domain parameter in elliptic curve cryptography, defined as the ratio between the order ...

are targets for

Mitogen-activated protein kinase A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to ...

(MAPK) signalling, and demonstrated that the MRTF transcription cofactors are novel

G-actin Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over ...

binding proteins that sense fluctuations in G-actin concentration. He continues to focus on SRF's regulatory cofactors and their cognate signalling pathways. Treisman was Director of the

Cancer Research UK Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

(CRUK)

London Research Institute The Cancer Research UK London Research Institute (LRI) was a biological research facility which conducted research into the basic biology of cancer. The LRI officially became a part of the Francis Crick Institute ("the Crick") in April 2015, rese ...

from 2000 to 2015, becoming Research Director of the Francis Crick Institute in 2009.

Awards and honours

Treisman was elected a member of the

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

and a

Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...

(FMedSci); he received the

EMBO Gold Medal The EMBO Gold Medal is an annual award of the European Molecular Biology Organization (EMBO) given to young scientists for outstanding contributions to the life sciences in Europe. Laureates receive a medal and €10,000 and are invited to rec ...

in 1995 and the

Louis-Jeantet Prize for Medicine Established in 1986, the Louis-Jeantet Prizes are funded by the ''Fondation Louis-Jeantet'' and awarded each year to experienced researchers who have distinguished themselves in the field of biomedical research in one of the member states of t ...

in 2002.Louis-Jeantet Prize
/ref> He was elected a Fellow of the Royal Society (FRS) in 1994 and knighted in the

2016 Birthday Honours The 2016 Queen's Birthday Honours are appointments by some of the 16 Commonwealth realms of Queen Elizabeth II to various orders and honours to reward and highlight good works by citizens of those countries. The Birthday Honours are awarded as pa ...

References

{{DEFAULTSORT:Treisman, Richard Henry 1954 births Living people People educated at Haberdashers' Boys' School Alumni of Christ's College, Cambridge Alumni of University College London Fellows of the Royal Society Knights Bachelor Academics of the Francis Crick Institute