RhoGAP domain is an evolutionary conserved
protein domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...
of
GTPase activating protein GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are ...
s towards
Rho
Rho (uppercase Ρ, lowercase ρ or ; el, ρο or el, ρω, label=none) is the 17th letter of the Greek alphabet. In the system of Greek numerals it has a value of 100. It is derived from Phoenician letter res . Its uppercase form uses the sa ...
/
Rac/
Cdc42-like small
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
s.
Human proteins containing this domain
ABR;
ARHGAP1
Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene.
Interactions
ARHGAP1 has been shown to interact with:
* BNIP2
* CDC42, and
* RHOA
Transforming protein RhoA, also known as Ras homolog famil ...
;
ARHGAP10;
ARHGAP11A;
ARHGAP11B
''ARHGAP11B'' is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ''ARHGAP1 ...
;
ARHGAP12;
ARHGAP15;
ARHGAP17;
ARHGAP18;
ARHGAP19
Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ''ARHGAP19'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gene ...
;
ARHGAP20;
ARHGAP21;
ARHGAP22;
ARHGAP23;
ARHGAP24;
ARHGAP25;
ARHGAP26;
ARHGAP27;
ARHGAP28;
ARHGAP29;
ARHGAP30;
ARHGAP4;
ARHGAP5
Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ''ARHGAP5'' gene.
Function
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrol ...
;
ARHGAP6;
ARHGAP8;
ARHGAP9
Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ''ARHGAP9'' gene.
Function
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several ...
;
BCR;
BPGAP1;
C1;
C5orf5;
CDGAP;
CENTD1;
CENTD2;
CENTD3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ''ARAP3'' gene.
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and plec ...
;
CHN1
Chimerin 1 (CHN1), also known as alpha-1-chimerin, n-chimerin, is a protein which in humans is encoded by the ''CHN1'' gene.
Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain ...
;
CHN2
Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the ''CHN2'' gene.
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/diacylglycerol-type zinc finger, a Rho-GAP domain and an SH2 domain ...
;
DEPDC1;
DEPDC1A;
DEPDC1B;
DLC1
Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the ''DLC1'' gene.
This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p2 ...
;
FAM13A1;
FKSG42; GMIP;
GRLF1;
HMHA1
Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the ''HMHA1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''ge ...
;
INPP5B;
KIAA1688;
LOC553158;
MYO9A;
MYO9B
''MYO9B'' is a gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The ...
;
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the ''OCRL'' gene located on the X chromosome in humans.
This gene encodes an inositol polyphosphate 5-phosphatase. The ...
;
OPHN1;
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the ''PIK3R1'' gene.
Function
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The e ...
;
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the ''PIK3R2'' gene.
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.
Interactions
...
;
PRR5;
RACGAP1
Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''RACGAP1'' gene.
Function
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (s ...
;
RACGAP1P;
RALBP1
RalA-binding protein 1 is a protein that in humans is encoded by the ''RALBP1'' gene.
Interactions
RALBP1 has been shown to interact with:
* Cyclin B1,
* HSF1,
* RALA,
* RALB, and
* REPS2
RalBP1-associated Eps domain-containing protein 2 ...
;
RICH2
Rich may refer to:
Common uses
* Rich, an entity possessing wealth
* Rich, an intense flavor, color, sound, texture, or feeling
** Rich (wine), a descriptor in wine tasting
Places United States
* Rich, Mississippi, an unincorporated comm ...
;
RICS
The Royal Institution of Chartered Surveyors (RICS) is a global professional body for surveyors, founded in London in 1868. It works at a cross-governmental level, and aims to promote and enforce the highest international standards in the val ...
;
SH3BP1
SH3 domain-binding protein 1 is a protein that in humans is encoded by the ''SH3BP1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation ...
;
SLIT1
Slit homolog 1 protein is a protein that in humans is encoded by the ''SLIT1'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ' ...
;
SNX26;
SRGAP1;
SRGAP2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the ''SRGAP2'' gene. It is involved in neuronal migration and differentiation and plays a crit ...
;
SRGAP3;
STARD13
StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the ''STARD13'' gene and a member of the DLC family of proteins.
Function and structure
STAR ...
;
STARD8
StAR-related lipid transfer domain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a protein that in humans is encoded by the ''STARD8'' gene and is a member of the DLC family.
Structure and function
The protein is ...
;
SYDE1;
SYDE2;
Notes
References
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Protein domains
Peripheral membrane proteins
{{membrane-protein-stub