The direct repeat 1 (dr1) element is an
RNA element commonly found in the
3' UTR
In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. The 3′-UTR often contains regulatory regions that post-transcriptionally ...
of
Avian sarcoma,
Rous sarcoma and
Avian leukosis
Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals. ASLV replicates in chicken embryo fibroblasts, the cells that contr ...
viruses (
Alpharetrovirus
''Alpharetrovirus'' is a genus of the family Retroviridae. It has type C morphology. Members can cause sarcomas, other tumors, and anaemia of wild and domestic birds and also affect rats.
Species include the Rous sarcoma virus, avian leukosi ...
es and Avian type C
retroviruses
A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase e ...
). dr1 is required for efficient viral replication and is thought to be involved in
genomic
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
packaging although this may not be its only role.
References
External links
*
Cis-regulatory RNA elements
Alpharetroviruses
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