Retinoblastoma-like protein 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''RBL2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
Retinoblastoma-like protein 2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a h ...
,
*
BRF1
*
C-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the ''RAF1'' gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase ( ...
,
*
Cyclin E1
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the ''CCNE1'' gene.
Function
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protei ...
,
*
Cyclin-dependent kinase 2
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein ...
,
HDAC1
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the ''HDAC1'' gene.
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. T ...
,Prohibitin
Prohibitin, also known as PHB, is a protein that in humans is encoded by the ''PHB'' gene.
The ''Phb'' gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Ty ...
,RBBP8
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the ''RBBP8'' gene.
Function
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retin ...
.
See also
* Pocket protein family
Pocket protein family consists of three proteins:
* RB – Retinoblastoma protein
* p107 – Retinoblastoma-like protein 1
* p130 – Retinoblastoma-like protein 2
They play crucial roles in the metazoan cell cycle through interaction with membe ...
References
Further reading
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External links
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{{DEFAULTSORT:Retinoblastoma-Like Protein 2
Transcription factors