REST corepressor 1 also known as CoREST is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''RCOR1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining
neural cell
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. No ...
differentiation. The encoded protein binds to the
C-terminal
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When the protein is ...
domain of
REST
Rest or REST may refer to:
Relief from activity
* Sleep
** Bed rest
* Kneeling
* Lying (position)
* Sitting
* Squatting position
Structural support
* Structural support
** Rest (cue sports)
** Armrest
** Headrest
** Footrest
Arts and entert ...
(repressor element-1 silencing transcription factor).
Interactions
RCOR1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
*
HDAC1
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the ''HDAC1'' gene.
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. T ...
,
HDAC2
Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the ''HDAC2'' gene. It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the co ...
,[
* ]HMG20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the ''HMG20B'' gene.
Interactions
HMG20B has been shown to interact with:
* BRCA2
''BRCA2'' and ...
,REST
Rest or REST may refer to:
Relief from activity
* Sleep
** Bed rest
* Kneeling
* Lying (position)
* Sitting
* Squatting position
Structural support
* Structural support
** Rest (cue sports)
** Armrest
** Headrest
** Footrest
Arts and entert ...
PHF21A
PHD finger protein 21A is a protein that in humans is encoded by the ''PHF21A'' gene.
Function
BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific g ...
.
References
Further reading
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