The Razi Vaccine and Serum Research Institute (

romanized Romanization or romanisation, in linguistics, is the conversion of text from a different writing system to the Roman (Latin) script, or a system for doing so. Methods of romanization include transliteration, for representing written text, and ...

: ''Mo'asseseh-ye Tahqiqât-e Vâksan va Seromsâzi-e Râzi'') is an Iranian pharmaceutical and biological institute. It is located in the Hessarak district in

Karaj Karaj ( fa, کرج, ) is the capital of Alborz Province, Iran, and effectively a satellite city of Tehran. Although the county hosts a population around 1.97 million, as recorded in the 2016 census, most of the county is rugged mountain. The urb ...

Iran Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...

. The Institute was built as a national center with the purpose of countering

epidemics An epidemic (from Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics of infectious d ...

in domestic animals during

Reza Shah Reza Shah Pahlavi ( fa, رضا شاه پهلوی; ; originally Reza Khan (); 15 March 1878 – 26 July 1944) was an Iranian Officer (armed forces), military officer, politician (who served as Ministry of Defence and Armed Forces Logistics (Iran), ...

era. Further departments were installed, including those dedicated to human medicines. In modern years, the Institute has focused primarily on

nanomedicine Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and BioBrick, biological devices, to Nanoelectronics, nanoelectronic biosensors, and even possible future applicatio ...

and

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

. The Institute is known for its

anti-venom Anti-Venom is a fictional antihero appearing in Comic books published by Marvel Comics. It first appeared in '' The Amazing Spider-Man'' #569 (August 2008), and was created by Dan Slott and John Romita Jr. The creature belongs to a race of amorp ...

serums derived from

snake Snakes are elongated, Limbless vertebrate, limbless, carnivore, carnivorous reptiles of the suborder Serpentes . Like all other Squamata, squamates, snakes are ectothermic, amniote vertebrates covered in overlapping Scale (zoology), scales. Ma ...

and

scorpion Scorpions are predatory arachnids of the order Scorpiones. They have eight legs, and are easily recognized by a pair of grasping pincers and a narrow, segmented tail, often carried in a characteristic forward curve over the back and always end ...

venom Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved ''venom apparatus'', such as fangs or a sti ...

. It hosts some reference pharmaceutical laboratories with regional or state scopes.

Branches

The Institute has established regional branches in: * Arak *

Ahvaz Ahvaz ( fa, اهواز, Ahvâz ) is a city in the southwest of Iran and the capital of Khuzestan province. Ahvaz's population is about 1,300,000 and its built-up area with the nearby town of Sheybani is home to 1,136,989 inhabitants. It is hom ...

Kerman Kerman ( fa, كرمان, Kermân ; also romanization of Persian, romanized as Kermun and Karmana), known in ancient times as the satrapy of Carmania, is the capital city of Kerman Province, Iran. At the 2011 census, its population was 821,394, in ...

Mashhad Mashhad ( fa, مشهد, Mašhad ), also spelled Mashad, is the List of Iranian cities by population, second-most-populous city in Iran, located in the relatively remote north-east of the country about from Tehran. It serves as the capital of R ...

Marand Marand ( fa, مرند; ; also Romanized as Morand) is a city and capital of Marand County, East Azerbaijan Province, Iran. Marand is among major cities in the province. It is located in the north-west of capital of the province Tabriz. Marand ha ...

Shiraz Shiraz (; fa, شیراز, Širâz ) is the List of largest cities of Iran, fifth-most-populous city of Iran and the capital of Fars province, Fars Province, which has been historically known as Pars (Sasanian province), Pars () and Persis. As o ...

History

Production timeline

* 1924: Institution of the institute. * 1932: Louis Delpy, a French

veterinarian A veterinarian (vet), also known as a veterinary surgeon or veterinary physician, is a medical professional who practices veterinary medicine. They manage a wide range of health conditions and injuries in non-human animals. Along with this, vet ...

, drove the institute to overcome an epidemic of

cattle plague Rinderpest (also cattle plague or steppe murrain) was an infectious viral disease of cattle, domestic buffalo, and many other species of even-toed ungulates, including gaurs, buffaloes, large antelope, deer, giraffes, wildebeests, and warthog ...

in the region. * 1933:

Anthrax Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...

* 1935: Sheep Pox * 1936: Livestock

Gangrene Gangrene is a type of tissue death caused by a lack of blood supply. Symptoms may include a change in skin color to red or black, numbness, swelling, pain, skin breakdown, and coolness. The feet and hands are most commonly affected. If the ga ...

* 1937: Cattle Pasteurellosis * 1941: Serums and vaccines for

diphtheria Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...

and

tetanus Tetanus, also known as lockjaw, is a bacterial infection caused by ''Clostridium tetani'', and is characterized by muscle spasms. In the most common type, the spasms begin in the jaw and then progress to the rest of the body. Each spasm usually ...

* 1970:

Polio Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe s ...

* 1987:

Rubella Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus. This disease is often mild, with half of people not realizing that they are infected. A rash may start around two weeks after exposure and ...

and

Measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...

* 1998: Aleppo Boil * 1992: Foundation of the biotechnology department. * 1997: Enhancement of the biotechnology department. * 2010: The institute produced 1.7 billion doses of 57 types of vaccines, serums, and antigens per year. * 2012: Production of

transgenic animals Genetically modified animals are animals that have been genetically modified for a variety of purposes including producing drugs, enhancing yields, increasing resistance to disease, etc. The vast majority of genetically modified animals are at the ...

, creating

recombinant vaccines A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

through genetic engineering, developing antigens and diagnostic kits for medical and veterinary labs. * 2021: Razi Cov Pars: a

COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID19). Prior to the COVID19 pandemic, an e ...

Current research projects

* Creation of

stem cell In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

lines from mice fetuses through cloning * Design and production of engineered skin tissue * Molecular analysis of the

CDS The compact disc (CD) is a digital optical disc data storage format that was co-developed by Philips and Sony to store and play digital audio recordings. In August 1982, the first compact disc was manufactured. It was then released in Octo ...

gene in cattle to diagnose genetic defects * Production of hybrid cells * Production of

* Production of a

monoclonal Monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus "monoclonal cells" can be said to form a single clone. The term ''monoclonal'' comes from the Ancient Greek ''monos'', meaning "alone" o ...

antibody for

measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...

History points

* The facility was used as a Soviet

military base A military base is a facility directly owned and operated by or for the military or one of its branches that shelters military equipment and personnel, and facilitates training and operations. A military base always provides accommodations for ...

during

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...

NATO The North Atlantic Treaty Organization (NATO, ; french: Organisation du traité de l'Atlantique nord, ), also called the North Atlantic Alliance, is an intergovernmental military alliance between 30 member states – 28 European and two No ...

forces used some of the Institute's anti-venom products during the

Afghanistan war War in Afghanistan, Afghan war, or Afghan civil war may refer to: *Conquest of Afghanistan by Alexander the Great (330 BC – 327 BC) *Muslim conquests of Afghanistan (637–709) *Conquest of Afghanistan by the Mongol Empire (13th century), see als ...

, since Afghan native snakes had not been researched in the USA or Europe.

References

External links

* {{authority control Pharmaceutical research institutes 1924 establishments in Iran Medical and health organisations based in Iran Research institutes established in 1924 Medical research institutes in Iran COVID-19 vaccine producers