The term radiogenomics is used in two contexts: either to refer to the study of genetic variation associated with response to radiation (radiation genomics) or to refer to the correlation between cancer imaging features and gene expression (imaging genomics).

Radiation genomics

In radiation genomics, radiogenomics is used to refer to the study of

genetic variation Genetic variation is the difference in DNA among individuals or the differences between populations. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, ...

associated with response to

radiation therapy Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radia ...

. Genetic variation, such as

single nucleotide polymorphisms In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently larg ...

, is studied in relation to a cancer patient's risk of developing toxicity following

. It is also used in the context of studying the

genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...

of tumor response to

. The term radiogenomics was coined in 2002 by Andreassen et al. (2002) as an analogy to

pharmacogenomics Pharmacogenomics is the study of the role of the genome in drug response. Its name ('' pharmaco-'' + ''genomics'') reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects the ...

, which studies the genetic variation associated with drug responses. See also West et al. (2005) and Bentzen (2006).

The Radiogenomics Consortium

In 2009, a Radiogenomics Consortium (RGC) was established to facilitate and promote multi-centre collaboration of researchers linking genetic variants with response to radiation therapy. The Radiogenomics Consortium (http://epi.grants.cancer.gov/radiogenomics/) is a Cancer Epidemiology Consortium supported by the Epidemiology and Genetics Research Program of the National Cancer Institute of the National Institutes of Health. RGC researchers have completed numerous clinical studies that identified genetic variants associated with radiation toxicities in patients with prostate, breast, lung, head and neck, and other cancers.

Past meetings

* 2009 - Manchester, UK. Consortium proposed. * 2010 - New York, USA. * 2011 - London, UK. * 2012 - Boston, USA. * 2013 - Cambridge (also REQUITE launch), UK. * 2014 - Heidelberg, Germany. * 2015 - Montpellier, France. * 2016 - Maastricht, Netherlands. * 2017 - Barcelona, Spain. * 2018 - Manchester, UK. * 2019 - Rochester, USA. * 2020 - Online. * 2021 - Online. * 2022 - Groningen, Netherlands. * 2023 - Manchester, UK.

Imaging genomics
Radiomics In the field of medicine, radiomics is a method that extracts a large number of features from medical images using data-characterisation algorithms. These features, termed radiomic features, have the potential to uncover tumoral patterns and char ...

Radiological images are used to diagnose disease on a large scale: tissue imaging correlates with tissue

pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...

. The addition of genomic data including

DNA microarrays A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to ...

miRNA MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRN ...

RNA-Seq RNA-Seq (named as an abbreviation of RNA sequencing) is a sequencing technique which uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment, analyzing the continuously changing c ...

allows new correlations to be made between cellular genomics and tissue-scale imaging.

Radiation genomics

The Radiogenomics Consortium

Past meetings

Imaging genomics
Radiomics In the field of medicine, radiomics is a method that extracts a large number of features from medical images using data-characterisation algorithms. These features, termed radiomic features, have the potential to uncover tumoral patterns and char ...

See also

References

Further reading

Radiation genomics

The Radiogenomics Consortium

Past meetings

Imaging genomics Radiomics In the field of medicine, radiomics is a method that extracts a large number of features from medical images using data-characterisation algorithms. These features, termed radiomic features, have the potential to uncover tumoral patterns and char ...

See also

References

Further reading

Imaging genomics
Radiomics In the field of medicine, radiomics is a method that extracts a large number of features from medical images using data-characterisation algorithms. These features, termed radiomic features, have the potential to uncover tumoral patterns and char ...