(–)-2β-(3-Methylisoxazol-5-yl)-3β-(p-
tolyl
In organic chemistry, tolyl groups are functional groups related to toluene. They have the general formula , the change of the relative position of the methyl and the R substituent on the aromatic ring can generate three possible structural i ...
)tropane (RTI-''4229''-171) is a
phenyltropane
Phenyltropanes (PTs) were originally developed to reduce cocaine addiction and dependency. In general these compounds act as inhibitors of the plasmalemmal monoamine reuptake transporters. Although RTI holds a strong position in this field, the ...
derivative which acts as a selective
dopamine reuptake inhibitor
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopa ...
, with a relatively slow onset of action and short duration of effects found in animal studies.
However, other studies have shown it to have the most pronounced effects in terms of speed of onset and rate of stimulation among many differing phenyltropanes.
See also
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List of phenyltropanes
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RTI-126
RTI-126 (RTI-''4229''-126 or (–)-2β-(1,2,4-oxadiazol-5-methyl)-3β-phenyltropane) is a phenyltropane derivative which acts as a potent monoamine reuptake inhibitor and stimulant drug, and has been sold as a designer drug. It is around 5 times ...
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O-4210
O-4210 is a drug developed by Organix Inc which acts as a selective dopamine reuptake inhibitor, with good selectivity over the serotonin transporter but its activity at the noradrenaline transporter is not known. It is a thiatropane derivative, ...
References
Tropanes
RTI compounds
Dopamine reuptake inhibitors
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