RQ-00203078 is a drug which acts as a potent and selective blocker of the
TRPM8 ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...
, which is the main receptor responsible for the sensation of
cold. It was developed as a potential
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
, and blocks the development of
hyperalgesia following exposure to cold temperatures or chronic
morphine administration.
See also
*
AMG-333
*
PF-05105679
References
Pyridines
Trifluoromethyl ethers
Trifluoromethyl compounds
Carboxylic acids
Chloroarenes
Sulfamates
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