DNA-directed RNA polymerase II subunit RPB2 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''POLR2B''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
Interactions
POLR2B has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
POLR2C
DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the ''POLR2C'' gene.
Function
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in ...
,
POLR2E
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the ''POLR2E'' gene.
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA ...
,
[ ]POLR2H
DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the ''POLR2H'' gene.
This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed ...
[ and ]POLR2L
DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the ''POLR2L'' gene.
Function
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in e ...
.[
]
References
Further reading
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