E3 ubiquitin-protein ligase RING2 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''RNF2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
(PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
Interactions
RNF2 has been shown to
interact
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with
TFCP2
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the ''TFCP2'' gene.
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcin ...
and
HIP2
Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the ''UBE2K'' gene.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of hunti ...
.
See also
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RING finger domain
In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arrange ...
References
Further reading
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External links
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RING finger proteins
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