RNAIII is a stable 514 nt regulatory RNA
transcribe
Transcription refers to the process of converting sounds (voice, music etc.) into letters or musical notes, or producing a copy of something in another medium, including:
Genetics
* Transcription (biology), the copying of DNA into RNA, the fir ...
d by the P3
promoter of the ''
Staphylococcus aureus''
quorum-sensing ''
agr'' system
). It is the major effector of the ''agr''
regulon
In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator. This terminology is generally, although not exclusiv ...
, which controls the expression of many ''
S. aureus'' genes encoding
exoproteins and cell wall associated proteins plus others encoding regulatory proteins
The RNAIII transcript also encodes the 26 amino acid δ-haemolysin (
S''taphylococcus aureus'' delta toxin) peptide (Hld).
RNAIII contains many stem loops, most of which match the
Shine-Dalgarno sequence involved in
translation
Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text. The English language draws a terminological distinction (which does not exist in every language) between ''transla ...
initiation of the regulated genes.
Some of these interactions are inhibitory, others stimulatory; among the former is the regulatory protein Rot. In vitro, RNAIII is expressed post exponentially, inhibiting translation of the surface proteins, notably protein A, while stimulating that of the exoproteins, many of which are tissue-degrading enzymes or
cytolysins. Among the latter is the important virulence factor, α-hemolysin (or
alpha toxin) (Hla), whose translation RNAIII activates by preventing the formation of an inhibitory foldback loop in the ''hla''
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein.
mRNA is created during the ...
leader.
References
Further reading
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External links
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Non-coding RNA
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