RJR-2429 is a drug that acts as an agonist at neural

nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ner ...

s, binding to both the α3β4 and the α4β2 subtypes. RJR-2429 is stronger than

nicotine Nicotine is a natural product, naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and ''Duboisia hopwoodii'') and is widely used recreational drug use, recreationally as a stimulant and anxiolytic. As ...

but weaker than

epibatidine Epibatidine is a chlorinated alkaloid that is secreted by the Ecuadoran frog ''Epipedobates anthonyi'' and poison dart frogs from the Ameerega genus. It was discovered by John W. Daly in 1974, but its structure was not fully elucidated until 19 ...

in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype.

References

Nicotinic agonists Nitrogen heterocycles {{nervous-system-drug-stub