Regulator of G-protein signaling 5 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''RGS5''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.
Interactions
RGS5 has been shown to
interact
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with
GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the ''GNAO1'' gene.
Mutations in this gene have been shown to cause epileptic encephalopathy.
Interactions
GNAO1 has been shown to interact with:
* ...
,
GNAI2
Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the ''GNAI2'' gene.
Interactions
GNAI2 has been shown to interact with:
* EYA2,
* GPSM2,
* Interleukin 8 receptor, alpha,
* MDFI,
* RGS5, ...
[ and GNAI3.][
]
References
Further reading
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