Regulator of G-protein signaling 19 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''RGS19''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.
Interactions
RGS19 has been shown to
interact
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with
GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the ''GNAO1'' gene.
Mutations in this gene have been shown to cause epileptic encephalopathy.
Interactions
GNAO1 has been shown to interact with:
* ...
,
GIPC1
GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the ''GIPC1'' gene. GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G prot ...
,
OSTM1
Osteopetrosis-associated transmembrane protein 1 is a protein that in humans is encoded by the ''OSTM1'' gene. It is required for osteoclast and melanocyte maturation and function.
Function
This gene encodes a protein that may be involved in ...
,
GNAI1
Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the ''GNAI1'' gene.
Interactive pathway map
Interactions
GNAI1 has been shown to interact with:
* GPR143,
* RGS12,
* RGS14,
* RGS19,
* R ...
,
[ ]GNAI3
Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the ''GNAI3'' gene.
Interactions
GNAI3 has been shown to interact with:
* RGS10
* RGS12,
* RGS14,
* RGS16,
* RGS18,
* RGS19,
* RGS5,
* RIC8A, ...
[ and ]GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the ''GNAZ'' gene.
Function
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis tox ...
.
References
Further reading
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External links
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{{PDB Gallery, geneid=10287