RalBP1-associated Eps domain-containing protein 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''REPS2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Interactions
REPS2 has been shown to
interact
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with
EPN1
Epsin-1 is a protein that in humans is encoded by the ''EPN1'' gene.
EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), ...
,
EPS15 and
RALBP1
RalA-binding protein 1 is a protein that in humans is encoded by the ''RALBP1'' gene.
Interactions
RALBP1 has been shown to interact with:
* Cyclin B1,
* HSF1,
* RALA,
* RALB, and
* REPS2
RalBP1-associated Eps domain-containing protei ...
.
References
Further reading
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{{gene-X-stub
EH-domain-containing proteins