Ran-specific binding protein 1 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''RANBP1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Ran
Ran, RaN and ran may refer to:
Arts and entertainment
* ''Ran'' (film), a 1985 film directed by Akira Kurosawa
* "Ran" (song), a 2013 Japanese song by Luna Sea
* '' Ran Online'', a 2004 MMORPG (massively multiplayer online role playing game)
* ...
/TC4-binding protein, RanBP1, interacts specifically with
GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not
GDP
Gross domestic product (GDP) is a monetary measure of the market value of all the final goods and services produced and sold (not resold) in a specific time period by countries. Due to its complex and subjective nature this measure is ofte ...
. RANBP1 does not activate
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (
RANGAP1
Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''RANGAP1'' gene.
Function
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanG ...
). The RANBP1
cDNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single-stranded RNA (e.g., messenger RNA (mRNA) or microRNA (miRNA)) template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA is often used to express a speci ...
encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of
RCC1
Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.
RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.
Interactions
...
by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
Interactions
RANBP1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
XPO1
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
History
XPO1 (CRM1) originally was identified in the fission yeast ''Schizosaccharom ...
,
KPNB1
Importin subunit beta-1 is a protein that in humans is encoded by the ''KPNB1'' gene.
Function
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. T ...
and Ran
Ran, RaN and ran may refer to:
Arts and entertainment
* ''Ran'' (film), a 1985 film directed by Akira Kurosawa
* "Ran" (song), a 2013 Japanese song by Luna Sea
* '' Ran Online'', a 2004 MMORPG (massively multiplayer online role playing game)
* ...
.
References
Further reading
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{{PDB Gallery, geneid=5902