UV excision repair protein RAD23 homolog A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''RAD23A''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is one of two human homologs of ''Saccharomyces cerevisiae'' Rad23, a protein involved in
nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of
3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in
base excision repair
Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from t ...
. This protein contains an
N-terminal ubiquitin-like domain, which was reported to interact with
26S proteasome, as well as with ubiquitin protein ligase
E6AP
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the ''UBE3A'' gene. This enzyme is involved in targeting proteins for degradation within cells.
Protein degradation ...
, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Interactions
RAD23A has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
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Ataxin 3,
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PSMD4,
and
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Sequestosome 1
Sequestosome-1 is a protein that in humans is encoded by the ''SQSTM1'' gene. Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacti ...
.
References
Further reading
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