Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''RAB11FIP1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Proteins of the large
Rab GTPase family (see for example
RAB1A
Ras-related protein Rab-1A is a protein that in humans is encoded by the ''RAB1A'' gene.
Interactions
RAB1A has been shown to interact
Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth ...
) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.
RAB11FIP1 has been identified as a novel protein involved in the regulation of
adiponectin trafficking and release from the adipocyte.
RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.
Interactions
RAB11FIP1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
RAB11A and
RAB4A
Ras-related protein Rab-4A is a protein that in humans is encoded by the ''RAB4A'' gene.
Interactions
RAB4A has been shown to interact with:
* CD2AP,
* KIF3B,
* RAB11FIP1,
* RABEP1
Rab GTPase-binding effector protein 1 is an enzyme that i ...
.
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References
Further reading
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