Quinolinate synthase (, ''NadA'', ''QS'', ''quinolinate synthetase'') is an
enzyme with
systematic name ''glycerone phosphate:iminosuccinate alkyltransferase (cyclizing)''.
This enzyme
catalyses the following
chemical reaction
:
glycerone phosphate
Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH2C(O)CH2OPO32-. This anion is involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis.Nelson, D. L.; Co ...
+
iminosuccinate
Iminoaspartic acid (also known as iminosuccinate or iminoaspartate) is a dicarboxylic acid in the biosynthesis of nicotinic acid. It is synthesised by the oxidation of aspartate and is condensed by quinolinate synthase with glycerone phosphate to ...
pyridine-2,3-dicarboxylate + 2 H
2O +
phosphate
This iron-sulfur protein that requires a
Fe-4Scluster for activity.
References
External links
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EC 2.5.1