Isoquercetin, isoquercitrin or isotrifoliin is a flavonoid, a type of chemical compound. It is the 3-''O''- glucoside of

quercetin Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor ...

. Isoquercitrin can be isolated from various plant species including ''

Mangifera indica ''Mangifera indica'', commonly known as mango, is a species of flowering plant in the family Anacardiaceae. It is a large fruit tree, capable of growing to a height of . There are two distinct genetic populations in modern mangoesthe "Indian ty ...

'' ( mango) and '' Rheum nobile'' (the Noble rhubarb). It is also present in the leaves of ''

Annona squamosa ''Annona squamosa'' is a small, well-branched tree or shrub from the family Annonaceae that bears edible fruits called sugar-apples or . It tolerates a tropical lowland climate better than its relatives '' Annona reticulata'' and ''Annona cherim ...

'', '' Camellia sinensis'' (

tea Tea is an aromatic beverage prepared by pouring hot or boiling water over cured or fresh leaves of ''Camellia sinensis'', an evergreen shrub native to East Asia which probably originated in the borderlands of southwestern China and north ...

). and '' Vestia foetida''

Spectral data

The lambda-max for isoquercetin is 254.8 and 352.6 nm.

Potential clinical uses

Isoquercetin is presently being investigated for prevention of

thromboembolism Thrombosis (from Ancient Greek "clotting") is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (t ...

in selected cancer patients and as an anti- fatigue agent in kidney cancer patients treated with sunitinib. There is a single case report of its use in the successful treatment of prurigo nodularis, a difficult to treat pruritic eruption of the skin. However it belongs to the PAINS (Pan-assay interference compounds) categories of chemicals.

Spectral data

Potential clinical uses

References

See also