Quinazolinone is a
heterocyclic chemical compound, a
quinazoline with a
carbonyl group in the C
4N
2 ring. Two
isomer
In chemistry, isomers are molecules or polyatomic ions with identical molecular formulae – that is, same number of atoms of each element – but distinct arrangements of atoms in space. Isomerism is existence or possibility of isomers.
Iso ...
s are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in
medicinal chemistry.
Synthesis
Common routes to quinazolines involve condensation of
amides to anilines with ortho nitrile, carboxylic acids and amides.
Quinazolinone drugs that function as
hypnotic
Hypnotic (from Greek ''Hypnos'', sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia ...
/
sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but t ...
s usually contain a 4-quinazolinone core with a 2-substituted
phenyl group
In organic chemistry, the phenyl group, or phenyl ring, is a cyclic group of atoms with the formula C6 H5, and is often represented by the symbol Ph. Phenyl group is closely related to benzene and can be viewed as a benzene ring, minus a hydrogen ...
at nitrogen atom 3.
See also
*
Idelalisib (Zydelig)
*
Methaqualone (Quaalude)
*
Cloroqualone
*
SL-164 (Dicloqualone)
*
Diproqualone
*
Etaqualone
*
Mebroqualone
*
Mecloqualone
*
Methylmethaqualone
*
Nitromethaqualone
References
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