In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a quercetin 2,3-dioxygenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:quercetin + O
2 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H
+
Thus, the two
substrates of this enzyme are
quercetin and
O2, whereas its 3
products are
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate,
CO, and
H+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on single donors with O
2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O
2. The
systematic name of this enzyme class is quercetin:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include quercetinase, and flavonol 2,4-oxygenase. It has 2
cofactors
Cofactor may also refer to:
* Cofactor (biochemistry), a substance that needs to be present in addition to an enzyme for a certain reaction to be catalysed
* A domain parameter in elliptic curve cryptography, defined as the ratio between the order ...
:
iron, and
Copper.
Structural studies
As of late 2007, 6
crystal structures have been solved for this class of enzymes, with
PDB accession codes , , , , , and .
References
*
*
*
EC 1.13.11
Iron enzymes
Copper enzymes
Enzymes of known structure
Quercetin
{{1.13-enzyme-stub