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Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, was first described in the 19th century from plants of the genus '' Quassia'' from which it gets its name. It was isolated in 1937 and its structure elucidated in 1961.
They are a biologically potent class of natural products, possessing antimalarial, antifeedant, insecticidal, anti-inflammatory, and anticancer properties. The quassinoid bruceantin reached two separate phase II clinical trials in 1982 and 1983.
Other quassinoids include:
*
Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, was first described in the 19th century from plants of the genus '' Quassia'' from which it gets its name. It was isolated in 1937 and its structure elucidated in 1961.
They are a biologically potent class of natural products, possessing antimalarial, antifeedant, insecticidal, anti-inflammatory, and anticancer properties. The quassinoid bruceantin reached two separate phase II clinical trials in 1982 and 1983.
Other quassinoids include:
* Bruceanol Bruceanol A-H
Bruceanols are quassinoid
Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, wa ...
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* Bruceolide
Bruceolide is a quassinoid that has been isolated from '' Bischofia javanica''. Synthetic derivatives have shown ''in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biologic ...
* Eurycomanone
Eurycomanone is a chemical compound that has been isolated from ''Eurycoma longifolia'', also known as the longjack plant or tongkat ali.
Mechanism of action
Eurycomanone is thought to be central to the sex-hormone increasing effects of ''Euryc ...
* Gutolactone
Gutolactone is a chemical compound extracted from '' Simaba guianensis'' and it has displayed antimalarial properties ''in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biol ...
* Isobrucein A
* Neoquassin
* Nigakihemiacetal A
* Quassimarin
* Samaderines
* Simalikalactones
References
External links
* * {{wiktionary inline, quassinoid Heterocyclic compounds with 4 rings