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QIAGEN Silicon Valley (formerly known as Ingenuity Systems, Inc) is a company based in
Redwood City, California Redwood City is a city on the San Francisco Peninsula in Northern California's Bay Area, approximately south of San Francisco, and northwest of San Jose. Redwood City's history spans its earliest inhabitation by the Ohlone people to being a ...
, USA, to analyze complex biological systems. QIAGEN Silicon Valley's first product, IPA, was introduced in 2003, and is used to help researchers analyze
omics The branches of science known informally as omics are various disciplines in biology whose names end in the suffix '' -omics'', such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. Omics aims at the collect ...
data and model biological systems. The software has been cited in thousands of scientific molecular biology publications and is one of several tools for
systems biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological syst ...
researchers and bioinformaticians in drug discovery and institutional research.


Technology

All QIAGEN Silicon Valley use the Ingenuity Knowledge Base, which contains biological and chemical interactions and functional annotations created from millions of individually modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases. Each relationship originates from reported experimental facts from primary literature sources, including peer-reviewed journal articles and textbooks. The knowledge acquisition and extraction process is protected by multiple US Patents.


Products and services

IPA is broadly adopted in the life science community and has been cited in thousands of peer-reviewed journal articles. IPA can be used with or without data. IPA helps researchers analyze data derived from expression and SNP microarrays, proteomics experiments, and small-scale experiments that generate gene lists, in order to gain insight into molecular and chemical interactions, cellular phenotypes, and disease processes within a system. IPA also lets researchers search for information on genes, proteins, chemicals, drugs, and
reagent In chemistry, a reagent ( ) or analytical reagent is a substance or compound added to a system to cause a chemical reaction, or test if one occurs. The terms ''reactant'' and ''reagent'' are often used interchangeably, but reactant specifies a ...
s. Resulting information can be used to build biological models, design experiments, or get up to speed in an area of research. Ingenuity offers search and visualization tools for science related e-commerce websites. Ingenuity has two prominent partnerships.
Sigma-Aldrich Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company a ...
leverages Ingenuity technology in their Your Favorite Gene application, and BD Biosciences leverages Ingenuity technology in their BD Cell Pathways application.


Timeline

2003 - Ingenuity first offers Ingenuity Knowledge Base
2004 - Stanford University licenses IPA
2004 - Independent analysis finds significant ROI for pharmaceutical companies using IPA
2005 - US Food and Drug Administration adopts IPA to review pharmacogenomics submissions
2006 - Ingenuity enters into partnerships with Asuragen, Spotfire, Agilent, Genedata, and Inforsense
2007 - Ingenuity introduce
toxicology
an

capabilities within IPA 5.0
2007 - IPA 5.0 wins Best in Show - Best New Product at Bio-IT World
2007 - Ingenuity and FDA enter three year collaboration to enhance regulatory review process
2008 - IPA's newest feature, Path Designer, wins Best New Product at Molecular Medicine
2009 - Sigma Aldrich launches Your Favorite Gene - Powered by Ingenuity
2009 - BD Biosciences launches BD Cell Pathways, powered by Ingenuity
2011 - Ingenuity announces early access to Ingenuity iReport
2012 - Ingenuity announces commercial availability of Ingenuity iReport and Ingenuity Variant Analysis
2013 - Ingenuity announces collaborations with both Laboratory Corporation and
Quest Diagnostics Quest Diagnostics is an American clinical laboratory. A Fortune 500 company, Quest operates in the United States, Puerto Rico, Mexico, and Brazil. Quest also maintains collaborative agreements with various hospitals and clinics across the globe. ...
to develop a solution for scoring genetic variation for next generation sequencing data (NGS) and is purchased by QIAGEN in May of the same year


See also

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Systems biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological syst ...
*
Bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...
*
Computational genomics Computational genomics refers to the use of computational and statistical analysis to decipher biology from genome sequences and related data, including both DNA and RNA sequence as well as other "post-genomic" data (i.e., experimental data obtained ...
*
Computational biology Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has fo ...
* Microarray analysis *
DNA microarray A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to ...
*
Pathway analysis Pathway is the term from molecular biology for a curated schematic representation of a well characterized segment of the molecular physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a sig ...


References

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External links


ingenuity.com
Software companies based in California Software companies of the United States