PncA is a gene encoding
pyrazinamidase PncA is a gene encoding pyrazinamidase in ''Mycobacterium'' species. Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid
Pyrazinoic acid is a pyrazinamide metabolite. Possible role in tuberculosis treatment
Pyrazin ...
in ''
Mycobacterium
''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis ('' M. tuberculosis'') and ...
'' species.
Pyrazinamidase PncA is a gene encoding pyrazinamidase in ''Mycobacterium'' species. Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid
Pyrazinoic acid is a pyrazinamide metabolite. Possible role in tuberculosis treatment
Pyrazin ...
converts the drug
pyrazinamide
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It i ...
to the active form
pyrazinoic acid
Pyrazinoic acid is a pyrazinamide metabolite. Possible role in tuberculosis treatment
Pyrazinamid is currently used as a treatment for tuberculosis. Mycobacterium tuberculosis converts pyrazinamid into pyrazinoic acid. The use of pyrazinoic acid ...
. There is a strong correlation between mutations in pncA and resistance of ''
M. tuberculosis'' to pyrazinamide.
See also
*
Pyrazinamide
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It i ...
References
Enzymes
Prokaryote genes
Tuberculosis
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