Philip Showalter Hench (February 28, 1896 – March 30, 1965) was an American

physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...

. Hench, along with his

Mayo Clinic The Mayo Clinic () is a nonprofit American academic medical center focused on integrated health care, education, and research. It employs over 4,500 physicians and scientists, along with another 58,400 administrative and allied health staf ...

co-worker

Edward Calvin Kendall Edward Calvin Kendall (March 8, 1886 – May 4, 1972) was an American chemist. In 1950, Kendall was awarded the Nobel Prize for Physiology or Medicine along with Swiss chemist Tadeusz Reichstein and Mayo Clinic physician Philip S. Hench, for the ...

and

Swiss Swiss may refer to: * the adjectival form of Switzerland *Swiss people Places * Swiss, Missouri *Swiss, North Carolina * Swiss, West Virginia *Swiss, Wisconsin Other uses * Swiss-system tournament, in various games and sports * Swiss Internation ...

chemist

Tadeus Reichstein Tadeusz Reichstein (20 July 1897 – 1 August 1996) was a Polish-Swiss chemist and the Nobel Prize in Physiology or Medicine laureate (1950), which was awarded for his work on the isolation of cortisone. Early life Reichstein was born into a Po ...

was awarded the

Nobel Prize for Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according ...

in 1950 for the discovery of the hormone

cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enz ...

, and its application for the treatment of

rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are inv ...

. The Nobel Committee bestowed the award for the trio's "discoveries relating to the hormones of the

adrenal cortex The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. It is ...

, their structure and biological effects." Hench received his undergraduate education at

Lafayette College Lafayette College is a private liberal arts college in Easton, Pennsylvania. Founded in 1826 by James Madison Porter and other citizens in Easton, the college first held classes in 1832. The founders voted to name the college after General Laf ...

in Easton,

Pennsylvania Pennsylvania (; ( Pennsylvania Dutch: )), officially the Commonwealth of Pennsylvania, is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States. It borders Delaware to its southeast, ...

, and received his medical training at the

United States Army Medical Corps The Medical Corps (MC) of the U.S. Army is a staff corps (non-combat specialty branch) of the U.S. Army Medical Department (AMEDD) consisting of commissioned medical officers – physicians with either an M.D. or a D.O. degree, at least one ye ...

and the

University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the univers ...

. He began working at

in 1923, later serving as the head of the Department of Rheumatology. In addition to the Nobel Prize, Hench received many other awards and honors throughout his career. He also had a lifelong interest in the history and discovery of

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. ...

Early life

He attended

in Easton, Pennsylvania, where he obtained his Bachelor of Arts in 1916. After serving in the Medical Corps of the U.S. Army and the reserve corps to finish his medical training, he was awarded a doctorate in medicine from the

in 1920. Immediately after finishing his medical degree, Hench spent a year as an intern at St. Francis Hospital in Pittsburgh, and then he subsequently became a Fellow of the

Mayo Foundation The Mayo Clinic () is a nonprofit American academic An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membersh ...

. In 1928 and 1929, Hench furthered his education at

Freiburg University The University of Freiburg (colloquially german: Uni Freiburg), officially the Albert Ludwig University of Freiburg (german: Albert-Ludwigs-Universität Freiburg), is a public research university located in Freiburg im Breisgau, Baden-Württemb ...

and the von Müller Clinic in Munich.

Medical career

Hench started his career at

in 1923, working in the Department of Rheumatic Diseases. In 1926, he became the head of the department. While at Mayo Clinic, Hench focused his work on arthritic diseases, where his observations led him to hypothesize that steroids alleviated pain associated with the disease. During this same time, biochemist

has isolated several steroids from the

adrenal gland The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer cortex ...

cortex. After several years of work, the duo decided to try one of these steroids (dubbed Compound E at the time, later to become known as

) on patients afflicted by

. Testing of the hypothesis was delayed because the synthesis of Compound E was costly and time-consuming, and Hench served in the military during

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...

. The tests were conducted successfully in 1948 and 1949. Hench, Kendall, and Swiss chemist

were awarded the 1950

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...

"for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects." As of the 2010 prizes, Hench and Kendall are the only two Nobel laureates affiliated with Mayo Clinic. Hench's Nobel Lecture was directly related to the research he was honored for, and titled "The Reversibility of Certain Rheumatic and Non-Rheumatic Conditions by the Use of Cortisone Or of the Pituitary Adrenocorticotropic Hormone". His speech at the banquet during the award ceremony acknowledged the connections between the study of medicine and chemistry, saying of his co-winners "Perhaps the ratio of one physician to two chemists is symbolic, since medicine is so firmly linked to chemistry by a double bond." During his career, Hench was one of the founding members of the American Rheumatism Association, and served as its president in 1940 and 1941. In addition to the Nobel Prize, Hench has been awarded the Heberdeen Medal (1942), the

Lasker Award The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was ...

(1949), the

Passano Foundation The Passano Foundation, established in 1945, provides an annual award to a research scientist whose work – done in the United States – is thought to have immediate practical benefits. Many Passano laureates have subsequently won the Nobel Priz ...

Award (1950), and the Criss Award. Lafayette College,

Washington and Jefferson College Washington & Jefferson College (W&J College or W&J) is a private liberal arts college in Washington, Pennsylvania. The college traces its origin to three log cabin colleges in Washington County established by three Presbyterian missionaries to ...

Western Reserve University Western may refer to: Places *Western, Nebraska, a village in the US *Western, New York, a town in the US * Western Creek, Tasmania, a locality in Australia *Western Junction, Tasmania, a locality in Australia *Western world, countries that i ...

, the

National University of Ireland The National University of Ireland (NUI) ( ga, Ollscoil na hÉireann) is a federal university system of ''constituent universities'' (previously called '' constituent colleges'') and ''recognised colleges'' set up under the Irish Universit ...

and the University of Pittsburgh awarded Hench honorary doctorates. In addition to his work with cortisone, Hench had a career long interest in

. Starting in 1937, Hench began to document the history behind the discovery of yellow fever. His collection of documents on this subject are at the

University of Virginia The University of Virginia (UVA) is a public research university in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, the university is ranked among the top academic institutions in the United States, with highly selective ad ...

in the Philip S. Hench Walter Reed Yellow Fever Collection. His wife donated the collection to the university after his death.

Family

Hench married Mary Kahler (1905-1982) in 1927. His father-in-law, John Henry Kahler, was a friend of Mayo Clinic founder William J. Mayo. Hench and his wife had four children, two daughters and two sons. His son, Philip Kahler Hench also studied rheumatology. Hench died of pneumonia while on vacation in

Ocho Rios, Jamaica Ocho Rios (Spanish for "Eight Rivers") is a town in the parish of Saint Ann on the north coast of Jamaica, and is more widely referred to as ''Ochi'' by locals. Beginning as a sleepy fishing village, Ocho Rios has seen explosive growth in the ...

in 1965.

References

External links

* including the Nobel Lecture, December 11, 1950 ''The Reversibility of Certain Rheumatic and Non-Rheumatic Conditions by the Use of Cortisone Or of the Pituitary Adrenocorticotropic Hormone''
BiographyUniversity of Virginia Health Sciences Library, A Guide to the Philip S. Hench Walter Reed Yellow Fever Collection
{{DEFAULTSORT:Hench, Philip Showalter 1896 births University of Freiburg alumni 1965 deaths Nobel laureates in Physiology or Medicine American Nobel laureates American endocrinologists Physicians of the Mayo Clinic University of Pittsburgh School of Medicine alumni United States Army Medical Corps officers United States Army personnel of World War I United States Army personnel of World War II Recipients of the Lasker-DeBakey Clinical Medical Research Award Lafayette College alumni Infectious disease deaths in Jamaica