Paul Greengard (December 11, 1925 – April 13, 2019) was an American

neuroscientist A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, Biological neural network, n ...

best known for his work on the

molecular A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and bioche ...

and

cellular Cellular may refer to: *Cellular automaton, a model in discrete mathematics * Cell biology, the evaluation of cells work and more * ''Cellular'' (film), a 2004 movie *Cellular frequencies, assigned to networks operating in cellular RF bands *Cell ...

function of

neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. N ...

s. In 2000, Greengard,

Arvid Carlsson Arvid Carlsson (25 January 1923 – 29 June 2018) was a Swedish neuropharmacologist who is best known for his work with the neurotransmitter dopamine and its effects in Parkinson's disease. For his work on dopamine, Carlsson was awarded the No ...

and

Eric Kandel Eric Richard Kandel (; born Erich Richard Kandel, November 7, 1929) is an Austrian-born American medical doctor who specialized in psychiatry, a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surge ...

were awarded the

Nobel Prize for Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according ...

for their discoveries concerning

signal transduction Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...

in the

nervous system In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes th ...

. He was

Vincent Astor William Vincent Astor (November 15, 1891 – February 3, 1959) was an American businessman, philanthropist, and member of the prominent Astor family. Early life Called Vincent, he was born in New York City on November 15, 1891. Astor was the eld ...

Professor at

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

, and served on the Scientific Advisory Board of the

Cure Alzheimer's Fund Cure Alzheimer's Fund (CAF) is an American non-profit organizationGuideStar Accessed 26 March 2014.Better Business Bureau. Accessed 26 March 2014. based in Wellesley, Massachusetts. It supports and funds research focusing on understanding and poten ...

, as well as the Scientific Council of the

Brain & Behavior Research Foundation The Brain & Behavior Research Foundation (BBRF) is a nonprofit 501(c)(3) organization that funds mental health Mental health encompasses emotional, psychological, and social well-being, influencing cognition, perception, and behavior. It like ...

. He was married to artist

Ursula von Rydingsvard Ursula von Rydingsvard (née Karoliszyn; born 1942) is a sculptor who lives and works in Brooklyn, New York. She is best known for creating large-scale works influenced by nature, primarily using cedar and other forms of timber. Early life and ...

Biography

Greengard was born in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

, the son of Pearl (née Meister) and Benjamin Greengard, a vaudeville comedian. His older sister was actress Irene Kane, who later became a writer by the name of

Chris Chase Chris Chase (born Irene Greengard; January 12, 1924 – October 31, 2013), also known by the stage name Irene Kane, was an American model, film actress, writer, and journalist.Miller, Betty Jean. (April 1, 1975). "Writing brings fame for Chris Ch ...

; she died in 2013, aged 89. Their mother died in childbirth and their father remarried in 1927. The Greengard siblings' parents were Jewish, but their stepmother was

Episcopalian Anglicanism is a Western Christian tradition that has developed from the practices, liturgy, and identity of the Church of England following the English Reformation, in the context of the Protestant Reformation in Europe. It is one of the l ...

. He and his sister were "brought up in the Christian tradition". During

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...

, he served in the

United States Navy The United States Navy (USN) is the maritime service branch of the United States Armed Forces and one of the eight uniformed services of the United States. It is the largest and most powerful navy in the world, with the estimated tonnage ...

as an

electronics The field of electronics is a branch of physics and electrical engineering that deals with the emission, behaviour and effects of electrons using electronic devices. Electronics uses active devices to control electron flow by amplification ...

technician at the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

working on an early warning system against Japanese

kamikaze , officially , were a part of the Japanese Special Attack Units of military aviators who flew suicide attacks for the Empire of Japan against Allied naval vessels in the closing stages of the Pacific campaign of World War II, intending to d ...

planes. After World War II, he attended

Hamilton College Hamilton College is a private liberal arts college in Clinton, Oneida County, New York. It was founded as Hamilton-Oneida Academy in 1793 and was chartered as Hamilton College in 1812 in honor of inaugural trustee Alexander Hamilton, following ...

where he graduated in 1948 with a bachelor's degree in

mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...

and

physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which r ...

. He decided against graduate school in physics because most post-war physics research was focusing on

nuclear weapon A nuclear weapon is an explosive device that derives its destructive force from nuclear reactions, either fission (fission bomb) or a combination of fission and fusion reactions ( thermonuclear bomb), producing a nuclear explosion. Both bom ...

s, and instead became interested in

biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. ...

. Greengard began his graduate studies at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...

in the lab of

Haldan Keffer Hartline Haldan Keffer Hartline (December 22, 1903 – March 17, 1983) was an American physiologist who was a co-recipient (with George Wald and Ragnar Granit) of the 1967 Nobel Prize in Physiology or Medicine for his work in analyzing the neurophysiolo ...

. Inspired by a lecture by

Alan Hodgkin Sir Alan Lloyd Hodgkin (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles. Early life and education Hodgkin was b ...

, Greengard began work on the molecular and cellular function of neurons. He received his PhD in 1953 and began postdoctoral work at the

University of London The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree ...

Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

, and the

University of Amsterdam The University of Amsterdam (abbreviated as UvA, nl, Universiteit van Amsterdam) is a public research university located in Amsterdam, Netherlands. The UvA is one of two large, publicly funded research universities in the city, the other being ...

. Greengard then became director of the Department of Biochemistry at the Geigy Research Laboratories. After leaving Geigy in 1967, he worked briefly at the

Albert Einstein College of Medicine Albert Einstein College of Medicine is a research-intensive medical school located in the Morris Park neighborhood of the Bronx in New York City. Founded in 1953, Einstein operates as an independent degree-granting institution as part of t ...

and

Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...

before taking a position as Professor in the Department of Pharmacology at

Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...

. In 1983 he joined the faculty of

The Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

. Greengard was a member of the Board of Scientific Governors at

The Scripps Research Institute Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institu ...

. He was the acting chairman of the Fisher Center for Alzheimer's Research Foundation and served on the board of the Michael Stern Parkinson's Research Foundation, which later merged with

The Michael J. Fox Foundation The Michael J. Fox Foundation for Parkinson's Research is dedicated to finding a cure for Parkinson's disease (PD) established in 2000 by Michael J. Fox. It concentrates on funding research and ensuring the development of improved therapies for ...

. Both internationally renowned foundations support the research conducted in the Greengard laboratory at

. He died on April 13, 2019.

Research

Greengard's research focused on events inside the neuron caused by

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neuro ...

s. Specifically, Greengard and his fellow researchers studied the behavior of

second messenger Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form or cell signaling, encompassing both first me ...

cascades that transform the docking of a neurotransmitter with a receptor into permanent changes in the neuron. In a series of experiments, Greengard and his colleagues showed that when

dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic compound, organic chemical of the catecholamine and phenethylamine families. Dopamine const ...

interacts with a

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

on the

cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment ( ...

of a neuron, it causes an increase in

cyclic AMP Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transd ...

inside the cell. This increase of cyclic AMP, in turn activates a protein called

protein kinase A In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (). PKA has several functions in the cell, including regulatio ...

, which turns other proteins on or off by adding

phosphate In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid . The phosphate or orthophosphate ion is derived from phospho ...

groups in a reaction known as

phosphorylation In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...

. The proteins activated by phosphorylation can then perform a number of changes in the cell: transcribing DNA to make new proteins, moving more receptors to the

synapse In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from ...

(and thus increasing the neuron's sensitivity), or moving

ion channel Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...

s to the cell surface (and thus increasing the cell's excitability). He shared the 2000 Nobel Prize in Physiology or Medicine with

and

for his work on the central regulatory protein

DARPP-32 Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the ''PPP1R1B'' gene. Function Midbrain dopaminergic neurons play a ...

Family

Paul Greengard had two sons from his first marriage, Claude and

Leslie Leslie may refer to: * Leslie (name), a name and list of people with the given name or surname, including fictional characters Families * Clan Leslie, a Scottish clan with the motto "grip fast" * Leslie (Russian nobility), a Russian noble family ...

. Claude Greengard holds a PhD in mathematics from

UC Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public university, public land-grant university, land-grant research university in Berkeley, California. Established in 1868 as the University of Californi ...

, and is the Founder of Foss Hill Partners. Leslie holds an MD from the

Yale School of Medicine The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary te ...

and a PhD in computer science from

, and is a professor of mathematics and computer science at and former director of the

Courant Institute of Mathematical Sciences The Courant Institute of Mathematical Sciences (commonly known as Courant or CIMS) is the mathematics research school of New York University (NYU), and is among the most prestigious mathematics schools and mathematical sciences research cente ...

NYU New York University (NYU) is a private university, private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-United States Secretary of the Treasu ...

, a winner of the

Steele Prize The Leroy P. Steele Prizes are awarded every year by the American Mathematical Society, for distinguished research work and writing in the field of mathematics. Since 1993, there has been a formal division into three categories. The prizes have ...

for a seminal contribution to research, a recipient of both a

Packard Foundation The David and Lucile Packard Foundation is a private foundation that provides grants to not-for-profit organizations. It was created in 1964 by David Packard (co-founder of HP) and his wife Lucile Salter Packard. Following David Packard's death ...

Fellowship and an

NSF NSF may stand for: Political organizations *National Socialist Front, a Swedish National Socialist party *NS-Frauenschaft, the women's wing of the former German Nazi party *National Students Federation, a leftist Pakistani students' political gr ...

Presidential Young Investigator Award The Presidential Young Investigator Award (PYI) was awarded by the National Science Foundation of the United States Federal Government. The program operated from 1984 to 1991, and was replaced by the NSF Young Investigator (NYI) Awards and Presiden ...

, and a member of both the U.S. National Academy of Engineering and the U.S. National Academy of Sciences. In 1985, Paul Greengard married internationally renowned sculptor

, who has received numerous awards and grants, including two awards from the

National Endowment of the Arts The National Endowment for the Arts (NEA) is an independent agency of the United States federal government that offers support and funding for projects exhibiting artistic excellence. It was created in 1965 as an independent agency of the federal ...

, a

Guggenheim Fellowship Guggenheim Fellowships are grants that have been awarded annually since by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the ar ...

, the Skowhegan Medal for Sculpture, and three awards from the American section of the International Association of Art Critics. von Rydingsvard is a member of the

American Academy of Arts and Letters The American Academy of Arts and Letters is a 300-member honor society whose goal is to "foster, assist, and sustain excellence" in American literature, music, and art. Its fixed number membership is elected for lifetime appointments. Its headqu ...

, and her artworks are among the permanent collections of the

Museum of Modern Art The Museum of Modern Art (MoMA) is an art museum located in Midtown Manhattan, New York City, on 53rd Street between Fifth and Sixth Avenues. It plays a major role in developing and collecting modern art, and is often identified as one of ...

, the

Metropolitan Museum of Art The Metropolitan Museum of Art of New York City, colloquially "the Met", is the largest art museum in the Americas. Its permanent collection contains over two million works, divided among 17 curatorial departments. The main building at 1000 ...

, The Brooklyn Museum, the Nelson-Atkins Museum of Art, the

National Gallery of Art The National Gallery of Art, and its attached Sculpture Garden, is a national art museum in Washington, D.C., United States, located on the National Mall, between 3rd and 9th Streets, at Constitution Avenue NW. Open to the public and free of char ...

and the Walker Art Center.

Discrimination complaints

In February 2018, a federal jury in the Southern District of New York found The Rockefeller University liable for discrimination based on race and national origin which occurred in 2007 in the lab of, and under the supervision of, Greengard.

Pearl Meister Greengard Prize

Paul Greengard used his Nobel Prize honorarium to help fund the

Pearl Meister Greengard Prize The Pearl Meister Greengard Prize is an award for women scientists in biology given annually by the Rockefeller University. The Prize was founded by Nobel laureate Paul Greengard and his wife Ursula von Rydingsvard in honor of Greengard's mothe ...

, an award for women scientists. The award is named after his mother, who died during childbirth. It was established in 2004 to shine a spotlight on exceptional

women in science The presence of women in science spans the earliest times of the history of science wherein they have made significant contributions. Historians with an interest in gender and science have researched the scientific endeavors and accomplishments ...

, since, as Greengard observed, "

omen An omen (also called ''portent'') is a phenomenon that is believed to foretell the future, often signifying the advent of change. It was commonly believed in ancient times, and still believed by some today, that omens bring divine messages fr ...

are not yet receiving awards and honors at a level commensurate with their achievements." The annual prize is awarded to an outstanding woman conducting biomedical research.

Awards and honors

* Elected member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(1978) * Elected member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

(1978) *

NAS Award in the Neurosciences The NAS Award in the Neurosciences is awarded by the U.S. National Academy of Sciences "in recognition of extraordinary contributions to progress in the fields of neuroscience, including neurochemistry, neurophysiology, neuropharmacology, developm ...

from the

(1991) *

Karl Spencer Lashley Award The Karl Spencer Lashley Award is awarded by The American Philosophical Society as a recognition of research on the integrative neuroscience of behavior. The award was established in 1957 by a gift from Dr. Karl Spencer Lashley. Recipients * 202 ...

(1993) * Elected member of the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

(1994) *Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet o ...

(2002) * Honoris causa degree in Medicine, (September 2007)

University of Brescia The University of Brescia ( it, Università degli Studi di Brescia) is an Italian public research university located in Brescia, Italy. It was founded in 1982 and is branched in 4 Faculties. The University of Brescia was officially established ...

* Member of the

Norwegian Academy of Science and Letters The Norwegian Academy of Science and Letters ( no, Det Norske Videnskaps-Akademi, DNVA) is a learned society based in Oslo, Norway. Its purpose is to support the advancement of science and scholarship in Norway. History The Royal Frederick Univer ...

References

Sources

* ''Les Prix Nobel''. 2001. The Nobel Prizes 2000, Editor Tore Frängsmyr, Nobel Foundation: Stockholm.

External links

* including the Nobel Lecture on 8 December 2000 ''The Neurobiology of Dopamine Signaling''
The Greengard Lab at The Rockefeller University

{{DEFAULTSORT:Greengard, Paul 1925 births 2019 deaths Nobel laureates in Physiology or Medicine American Nobel laureates Members of the United States National Academy of Sciences Jewish neuroscientists American cognitive neuroscientists Jewish physicians Hamilton College (New York) alumni Johns Hopkins University alumni Academics of the University of Cambridge Members of the Royal Swedish Academy of Sciences Members of the Serbian Academy of Sciences and Arts Scripps Research Members of the Norwegian Academy of Science and Letters Rockefeller University people Military personnel from New York City Scientists from New York City United States Navy personnel of World War II United States Navy sailors Members of the American Philosophical Society Members of the National Academy of Medicine