Protein Interacting with C Kinase - 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''PICK1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (
PRKCA
Protein kinase C alpha (PKCĪ±) is an enzyme that in humans is encoded by the ''PRKCA'' gene.
Function
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messe ...
). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Interactions
PICK1 has been shown to
interact
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with:
*
ACCN2
Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. The ASIC1 gene is one of the five paralogous gene ...
,
*
BNC1
Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the ''BNC1'' gene.
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in ...
,
[
* ]Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopam ...
,GRIA2
Glutamate ionotropic receptor AMPA type subunit 2 (Glutamate receptor 2, or GluR-2) is a protein that in humans is encoded by the ''GRIA2'' (or ''GLUR2'') gene and it is a subunit found in the AMPA receptors.
Function
Glutamate receptors are ...
,[
* ]GRIA3
Glutamate receptor 3 is a protein that in humans is encoded by the ''GRIA3'' gene.
Function
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophys ...
,[
* ]GRIA4
Glutamate receptor 4 is a protein that in humans is encoded by the ''GRIA4'' gene.
This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to t ...
,[
* ]GRIK1
Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the ''GRIK1'' gene.
Function
This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-ga ...
,GRIK2
Glutamate ionotropic receptor kainate type subunit 2, also known as ionotropic glutamate receptor 6 or GluR6, is a protein that in humans is encoded by the ''GRIK2'' (or ''GLUR6'') gene.
Function
This gene encodes a subunit of a kainate glut ...
,[
* ]GRIK3
Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the ''GRIK3'' gene.
This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heterome ...
,[
* ]HER2/neu
Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ''ERBB2'' gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently refer ...
,Metabotropic glutamate receptor 3
Metabotropic glutamate receptor 3 (mGluR3) is an inhibitory Gi/G0-coupled G-protein coupled receptor (GPCR) generally localized to presynaptic sites of neurons in classical circuits. However, in higher cortical circuits in primates, mGluR3 are lo ...
,Metabotropic glutamate receptor 7
Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the ''GRM7'' gene.
Function
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamat ...
.
References
Further reading
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External links
GenecardsMGI
{{PDB Gallery, geneid=9463