RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
.
The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of
GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.
The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of
aldosterone, suggesting that QRFP and GPR103 regulate
adrenal
The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer cortex whic ...
function.
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