2C-T-4 (2,5-dimethoxy-4-isopropylthiophenethylamine) is a

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amin ...

of the

2C family 2C (2C-''x'') is a general name for the family of psychedelic phenethylamines containing methoxy groups on the 2 and 5 positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the 4 position, usually resulting in ...

. It was first synthesized by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymethamph ...

and is used as

entheogen Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...

recreational drug Recreational drug use indicates the use of one or more psychoactive drugs to induce an altered state of consciousness either for pleasure or for some other casual purpose or pastime by modifying the perceptions and emotions of the user. When a ...

Chemistry

2C-T-4 is the 2-carbon

homolog In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of prima ...

aleph-4 Aleph (also known as DOT or 2,5-dimethoxy-4-methylthioamphetamine) is a psychedelic hallucinogenic drug and a substituted amphetamine of the phenethylamine class of compounds, which can be used as an entheogen. It was first synthesized by Ale ...

. The full chemical name is 2- -(isopropylThio-">thio)-2,5-dimethoxy">isopropyl">-(isopropyl<_a>Thio-.html" ;"title="isopropyl.html" ;"title="-(isopropyl">-(isopropylThio-">thio)-2,5-dimethoxyphenyl]-ethyl group, ethanamine. The drug has structure, structural and pharmacodynamic properties similar to 2C-T-7 and 2C-T-19.

Effects

2C-T-4 produces psychedelic and entheogenic effects that develop slowly and can last 8–16 hours. While users may experience virtually no effects for the first hour after ingestion, results vary drastically between individuals and range from

hallucination A hallucination is a perception in the absence of an external stimulus that has the qualities of a real perception. Hallucinations are vivid, substantial, and are perceived to be located in external objective space. Hallucination is a combinatio ...

and

euphoria Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and da ...

to intense sickness and anxiety. Shulgin devoted a chapter in the first part of his book '' PiHKAL'' to this compound, describing an intense "plus-four" psychedelic experience mediated by a twelve milligram dose.

Pharmacology

The mechanism that produces 2C-T-4’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT_2A

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.

Popularity

2C-T-4 is relatively unknown on the black market, but has been sold to a limited extent on the

research chemical Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only; a research chemical is not intended for human o ...

market.

Drug prohibition laws

Canada

As of October 31, 2016, 2C-T-4 is a controlled substance (Schedule III) in Canada.

China

As of October 2015 2C-T-4 is a controlled substance in China.

Denmark

2C-T-4 is added to the list of Schedule B controlled substances.

Sweden

''Sveriges riksdags'' health ministry ''Statens folkhälsoinstitut'' classified 2C-T-4 as "health hazard" under the act ''Lagen om förbud mot vissa hälsofarliga varor'' (translated ''Act on the Prohibition of Certain Goods Dangerous to Health'') as of Jul 15, 2007, in their regulation SFS 2007:600 listed as 2,5-dimetoxi-4-isopropyltiofenetylamin (2C-T-4), making it illegal to sell or possess.

United States

As of July 9, 2012, 2C-T-4 is a Schedule I substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.

Homologue

2C-T-4 has one homologue, the structural isomer Ψ-2C-T-4 (2,6-dimethoxy-4-(i)-propylthiophenethylamine). This compound was tested by

at a dose of 12 mg. At this dosage its duration was very short and it produced few effects, however based on the research into the better characterized compound Ψ-DOM, the potency of Ψ-2C-T-4 is likely to be around 1/3 that of 2C-T-4 itself, so a more effective dosage of Ψ-2C-T-4 might be in the region of 20–60 mg; however high doses such as this might well be associated with toxic side effects, and so extreme caution would be advised.

References

External links

PiHKAL #41 2C-T-4

2C-T-4 Entry in PiHKAL • info

Ψ-2C-T-4 Entry in PiHKAL • info
{{Hallucinogenic phenethylamines 2C (psychedelics) Thioethers Designer drugs Isopropyl compounds