Somatrem, sold under the brand name Protropin, is an
analogue of
growth hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in h ...
(GH).
Somatrem is a recombinant human growth hormone used for the treatment of short stature due to decreased or absent secretion of endogenous growth hormone. Somatrem was first marketed under the brand name Protropin by Genentech in 1985. It differs from endogenous growth hormone by the addition of an extra methionine at the
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
[ Growth hormone therapy#cite note-32]. Somatrem has largely been replaced by somatropin, marketed by several companies including by Genentech as the brand Nutropin.
References
External links
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Growth hormones
Peptides
Hoffmann-La Roche brands
Genentech brands
{{Systemic-hormonal-drug-stub