Proteus-like syndrome (PLS) is a condition similar to
Proteus syndrome
Proteus syndrome is a rare disorder with a genetic background that can cause tissue overgrowth involving all three embryonic lineages. Patients with Proteus syndrome tend to have an increased risk of embryonic tumor development.Freedberg, et al. ...
, but with an uncertain cause.
It's characterized by skeletal and hamartous overgrowth of multiple tissues, nevi in cerebriform connective tissue, blood vessel malformations and linear epidermal nevi.
It was featured aa the first story in the 7th episode of the 10th season of
Mystery Diagnosis
''Mystery Diagnosis'' is a television docudrama series that aired on Oprah Winfrey Network, OWN: Oprah Winfrey Network. Each episode focuses on two or more individuals who have struggled with obscure medical ailments, and their quest for a diagno ...
.
See also
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List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ...
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PTEN (gene)
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the ''PTEN'' gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate ca ...
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Multiple hamartoma syndrome
Multiple hamartoma syndrome is a syndrome characterized by more than one hamartoma.
It is sometimes equated with Cowden syndrome. However, MeSH also includes Bannayan–Zonana syndrome (that is, Bannayan–Riley–Ruvalcaba syndrome) and Lhermit ...
References
External links
GeneReviews/NCBI/NIH/UW entry on PTEN Hamartoma Tumor Syndrome (PHTS)
Deficiencies of intracellular signaling peptides and proteins
Genodermatoses
Syndromes
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