Protein-fructosamine 3-kinase (, ''
FN3K'', ''fructosamine 3-kinase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name ''ATP:(protein)-N
6-D-fructosyl-L-lysine 3-phosphotransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: ATP +
roteinN
6-D-fructosyl-L-lysine
ADP +
roteinN
6-(3-O-phospho-D-fructosyl)-L-lysine
Nonenzymatic
glycation
Glycation (sometimes called non-enzymatic glycosylation) is the covalent attachment of a sugar to a protein or lipid. Typical sugars that participate in glycation are glucose, fructose, and their derivatives. Glycation is the non-enzymatic proces ...
is a factor in the
pathogenesis of
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
.
References
External links
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EC 2.7.1