Prostaglandin E synthase (, or PGE synthase) is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

involved in

eicosanoid Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length. Eicosanoids are a s ...

and

glutathione Glutathione (GSH, ) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by sources such as reactive oxygen species, free radicals, pero ...

metabolism, a member of

MAPEG family In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions. Included are the 5-lipoxygenase-activating prot ...

. It generates

prostaglandin E Prostaglandin E is a family of naturally occurring prostaglandins that are used as medications. Types include: * Prostaglandin E1 also known as alprostadil * Prostaglandin E2 also known as dinoprostone Both types are on the World Health Org ...

(PGE) from

prostaglandin H2 Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. The conversion from Arachidonic acid to P ...

. The synthase generating PGE2 is a membrane-associated protein.

Isozymes

Humans express three prostaglandin-E synthase

isozyme In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. dif ...

s, each encoded by a separate gene:

References

External links

* * EC 5.3.99 {{enzyme-stub