Cause
PPD is due to a mutation in the Wnt1-inducible signalling protein 3 (WISP3) gene, which encodes a signalling factor involved in cartilage homeostasis.Symptoms
Symptoms are present typically between ages three and six years. * Abnormal walking pattern * Weakness/fatigue * Stiffness in the joints of the fingers and kneesDiagnosis
Treatment
Prognosis
PPD has no severe effect on life span.Epidemiology
PPD is an extremely rare disease. In the United States the disease is estimated to affect less than 5,000 people and approximately 1 per million people in the United Kingdom however it is believed to be more common in Turkey and the Middle East.References
{{reflist Rare diseases Osteopathies