Progressive osseous heteroplasia is a cutaneous condition characterized by cutaneous or subcutaneous ossification. According to the Progressive Osseous Heteroplasia Association: It is associated with '' GNAS''. A telltale symptom of POH is

osteoma cutis Osteoma cutis is a cutaneous condition characterized by the presence of bone within the skin in the absence of a preexisting or associated lesion. See also * Calcinosis cutis * Skin lesion * List of cutaneous conditions Many skin conditio ...

under the skin of a newborn. It was discovered in 1994 by physician Frederick Kaplan.

Diagnosis

Patients with POH have a distinctly different manifestation of symptoms than those with

fibrodysplasia ossificans progressiva Fibrodysplasia ossificans progressiva (; FOP; also called Münchmeyer disease and formerly called myositis ossificans progressiva or Stoneman disease) is an extremely rare connective tissue disease in which fibrous connective tissue such as mus ...

(FOP), though heterotopic ossification appears in both diseases. They lack the congenital abnormality of the big toe that is a diagnostic feature for FOP. People with POH also have ossification of the skin during infancy, which does not occur in FOP. Also, the pattern of ossification differs in POH, spreading in an intramembranous fashion rather than

endochondral Endochondral ossification is one of the two essential processes during fetal development of the mammalian skeletal system by which bone tissue is produced. Unlike intramembranous ossification, the other process by which bone tissue is produced, ...

References

External links

Genodermatoses Skeletal disorders {{Cutaneous-condition-stub