Pregnanetriol, or 5β-pregnane-3α,17α,20α-triol, is a
steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and a ...
and inactive
metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism.
The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, c ...
of
progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the m ...
.
Urine testing
Urine excretion of pregnanetriol can be measured over a period of 24 hours. Elevated urine pregnanetriol levels suggest
adrenogenital syndrome
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. It results from the deficiency of one of the five enzymes required for the synthesis of cortisol in the adrenal cortex. M ...
. In monitoring treatment with
cortisol replacement, elevated urine pregnanetriol levels indicate insufficient dosage of cortisol.
[online-family-doctor.com Pregnanetriol ]
Retrieved April 2011
Reference ranges
For females:
[
* 0 to 5 years: < 0.1 mg/24 hours
* 6 to 9 years: < 0.3 mg/24 hours
* 10 to 15 years: 0.1 to 0.6 mg/24 hours
* 16 years and older: 0 to 1.4 mg/ 24 hours.
For males:][
* 0 to 5 years: < 0.1 mg/24 hours
* 6 to 9 years: < 0.3 mg/24 hours
* 10 to 15 years: 0.2 to 0.6 mg/24 hours
* 16 years and older: 0.2 to 2 mg/ 24 hours
]
See also
Pregnanetriolone
References
5β-Pregnanes
Human metabolites
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