The potassium channel RNA editing signal is an RNA element found in human

Kv1.1 Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the ''KCNA1'' gene. Isaacs syndrome is a result of an autoimmune reaction against the Kv1 ...

and its homologues which directs the efficient modification of an adenosine to

inosine Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9- glycosidic bond. It was discovered in 1965 in analysis of RNA transferase. Inosine is commonly found in tRNAs and is ...

by an adenosine deaminase acting on RNA ( ADAR). The ADAR modification causes an isoleucine/

valine Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α- amino group (which is in the protonated −NH3+ form under biological conditions), an α- carboxylic acid group (which is in the deprotona ...

recoding event which lies in the ion-conducting pore of the

potassium channel Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of c ...

. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.

References

External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub