Polyuridylation, also called oligouridylation, is the addition of several

uridine Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond. The analog is one of the five standard nucleosides which make up nucle ...

nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated are histone mRNAs that lack a

poly(A) tail Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eu ...

. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in '' Arabidopsis'' and mouse have been seen to be polyuridinylated after cleavage.

References

RNA {{molecular-biology-stub