Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an
RNA-binding protein
RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells and participate in forming ribonucleoprotein complexes.
RBPs contain various structural motifs, such as RNA recognition moti ...
. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.
Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.
[ ][ ] These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.
See also
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Polypyrimidine tract {{Short description, A pyrimidine-rich sequence involved in pre-messenger RNA maturation
The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying ou ...
References
External links
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