Polycomb protein EED is a
protein that in humans is encoded by the ''EED''
gene.
Function
Polycomb protein EED is a member of the
Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of
integrin β7, immunodeficiency virus type 1 (HIV-1) MA protein, and
histone deacetylase
Histone deacetylases (, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around his ...
proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.
Clinical significance
In humans, a ''de-novo'' mutation in EED has been reported in an individual displaying symptoms similar to those of
Weaver syndrome.
Interactions
EED has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
EZH2,
[
* ITGB7,]
References
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