Poly ICLC is an
immunostimulant
Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colon ...
. It is
polyinosinic-polycytidylic acid
Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
Poly I:C is known to interact with toll-like receptor 3 ( TLR3), which is ...
(poly I:C) mixed with the stabilizers
carboxymethylcellulose and
polylysine.
It is under trial for use in cancer.
Poly I:C is a ligand for
toll like receptor-3
Toll-like receptor 3 (TLR3) also known as CD283 ( cluster of differentiation 283) is a protein that in humans is encoded by the ''TLR3'' gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate imm ...
, which usually triggers on the structurally similar
double-stranded RNA present in some viruses.
References
External links
* National Cancer Institute
poly ICLC
Immunostimulants
Combination drugs
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