Pocket protein family consists of three proteins:
* RB –
Retinoblastoma protein
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated ''Rb'', ''RB'' or ''RB1'') is a proto-oncogenic tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive ...
* p107 –
Retinoblastoma-like protein 1
Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the ''RBL1'' gene.
Function
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 ( RB1 ...
* p130 –
Retinoblastoma-like protein 2
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the ''RBL2'' gene.
Interactions
Retinoblastoma-like protein 2 has been shown to interact with:
* BRCA1,
* BRF1
* C-Raf,
* Cyclin E1,
* Cyclin-dependent kinase 2,
...
They play crucial roles in the
metazoan
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals Heterotroph, consume organic material, Cellular respiration#Aerobic respiration, breathe oxygen, are Motility, able to move, ca ...
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subs ...
through interaction with members of the
E2F transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s family.
References
{{Transcription factors, g0
Protein families