Placental site trophoblastic tumor is a form of
gestational trophoblastic disease, which is thought to arise from
intermediate trophoblast.
The tumor may secrete
human placental lactogen,
and result in a
false-positive pregnancy test.
A placental site trophoblastic tumor is a monophasic neoplasm of the
implantation site intermediate trophoblast, and usually a benign lesion, which comprises less than 2% of all gestational trophoblastic proliferations. Preceding conditions include molar pregnancy (5%). Compared to
choriocarcinoma or invasive mole, hemorrhage is less conspicuous and serum
β-HCG level is low, making early diagnosis difficult.
Immunohistochemistry
Immunohistochemistry (IHC) is the most common application of immunostaining. It involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to an ...
: Often stains with hPL, keratin, Mel-CAM, EGFR.
Treatment
Because
chemotherapy is ineffective; the patient should undergo
hysterectomy
Hysterectomy is the surgical removal of the uterus. It may also involve removal of the cervix, ovaries (oophorectomy), Fallopian tubes (salpingectomy), and other surrounding structures.
Usually performed by a gynecologist, a hysterectomy may b ...
.
Prognosis
10–20% of cases
metastasize leading to death.
References
External links
{{Germ cell tumors
Health issues in pregnancy
Germ cell neoplasia