Pinc (pregnancy induced noncoding RNA) is a
long non-coding RNA. It was originally identified in the
mammary glands
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in prima ...
of
oestrogen
Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activ ...
and
progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the m ...
-treated rats.
Pinc may be a
mammal
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...
-specific gene. It is conserved in a number of mammalian
genomes (
human,
mouse
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...
,
rat
Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include ''Neotoma'' ( pack rats), ''Bandicota'' (bandicoot ...
,
chimpanzee
The chimpanzee (''Pan troglodytes''), also known as simply the chimp, is a species of great ape native to the forest and savannah of tropical Africa. It has four confirmed subspecies and a fifth proposed subspecies. When its close relative th ...
,
dog,
cow and
opossum
Opossums () are members of the marsupial order Didelphimorphia () endemic to the Americas. The largest order of marsupials in the Western Hemisphere, it comprises 93 species in 18 genera. Opossums originated in South America and entered North ...
), but not in
fugu
The fugu (; ; ) in Japanese, ''bogeo'' (; 鰒魚) or ''bok'' () in Korean, and ''hétún'' (河豚; 河魨) in Standard Modern Chinese is a pufferfish, normally of the genus ''Takifugu'', ''Lagocephalus'', or ''Sphoeroides'', or a porcupinefish ...
,
zebrafish or
xenopus genomes.
In mice, Pinc is expressed in the developing
embryo
An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male spe ...
and in the mammary glands of adults. Its expression in the mammary gland is
induced
Induce may refer to:
* Induced consumption
* Induced innovation
* Induced character
* Induced coma
* Induced menopause
* Induced metric
* Induced path
* Induced topology
* Induce (musician), American musician
See also
* Inducement (disambiguation ...
by pregnancy and drops during
lactation. It may have a role in
cell survival and in the regulation of
cell cycle progression.
See also
*
Long noncoding RNA
References
Further reading
* {{cite journal , author=Mattick JS , title=The genetic signatures of noncoding RNAs , journal=PLOS Genet. , volume=5 , issue=4 , pages=e1000459 , date=April 2009 , pmid=19390609 , pmc=2667263 , doi=10.1371/journal.pgen.1000459 , editor1-last=Lee , editor1-first=Jeannie T.
External links
MGI entry for Pinc
Non-coding RNA