Pimitespib (trade name Jeselhy) is a drug for the treatment of

gastrointestinal stromal tumor Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is ...

s. It was discovered and developed by Taiho Pharmaceutical Co. The

mechanism of action In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targe ...

of pimitespib involves inhibition of heat shock protein 90 (Hsp90). In June 2022, it received approval in Japan for gastrointestinal stromal tumors that have progressed after chemotherapy.

References

Antineoplastic drugs Pyrazoles Benzamides Imidazoles Pyrazolopyridines {{antineoplastic-drug-stub