Pierre Chambon (born 7 February 1931 in

Mulhouse, France Mulhouse (; Alsatian: or , ; ; meaning ''mill house'') is a city of the Haut-Rhin department, in the Grand Est region, eastern France, close to the Swiss and German borders. It is the largest city in Haut-Rhin and second largest in Alsace a ...

) was the founder of the in

Strasbourg Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eu ...

France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...

. He was one of the leading molecular biologists who utilized gene cloning and sequencing technology to first decipher the structure of eukaryotic genes and their modes of regulation. His major contributions to science include the identification of RNA polymerase II(B), the identification of transcriptional control elements, the cloning and dissection of

nuclear hormone receptor In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of speci ...

s, revealing their structure and showing how they contribute to human

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

. His group was also one of the first to demonstrate, biochemically and electron-microscopically, that the nucleosome is the smallest unit of chromatin (Cell, Vol. 4, 281–300, 1975). He accomplished much of his work in the 1970-90s. Chambon was elected a Foreign Associate of the US

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

and to the French

Académie des Sciences The French Academy of Sciences (French: ''Académie des sciences'') is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French scientific research. It was at the ...

in 1985, a foreign member of the

Royal Swedish Academy of Sciences The Royal Swedish Academy of Sciences ( sv, Kungliga Vetenskapsakademien) is one of the Swedish Royal Academies, royal academies of Sweden. Founded on 2 June 1739, it is an independent, non-governmental scientific organization that takes special ...

in 1987. He was awarded the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1999 and a second time in 2018. In 2003 he was awarded the

March of Dimes Prize in Developmental Biology The March of Dimes Prize in Developmental Biology is awarded once a year by the March of Dimes. It carries a $250,000 award "to an investigator whose research brings us closer to the day when all babies will be born healthy." It also includes a ...

. He received the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

in 2004 for his work in the field. In 2010, Chambon was awarded the

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

"for the elucidation of fundamental mechanisms of transcription in animal cells and to the discovery of the nuclear receptor superfamily". In 2018 he received the

for a second time.Louisa Gross Horwitz Prize 2018
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Notes

References

External links

The Official Site of Louisa Gross Horwitz Prize

ISI Highly Cited page
Living people 1931 births Collège de France faculty Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Members of the Royal Swedish Academy of Sciences French molecular biologists French geneticists French endocrinologists French people of Jewish descent Scientists from Mulhouse University of Strasbourg alumni Recipients of the Albert Lasker Award for Basic Medical Research Fellows of the AACR Academy Commandeurs of the Légion d'honneur Grand Officers of the Ordre national du Mérite Richard-Lounsbery Award laureates {{biologist-stub