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The term phrenitis was employed in ancient Greece by
Hippocrates
Hippocrates of Kos (; grc-gre, Ἱπποκράτης ὁ Κῷος, Hippokrátēs ho Kôios; ), also known as Hippocrates II, was a Greek physician of the classical period who is considered one of the most outstanding figures in the history of ...
and his followers. It refers to acute inflammation of mind and body, not in a theoretical but in a descriptive sense. Its presumed seat was never anatomically or conceptually well determined. The diagnosis was used during the
Middle Ages
In the history of Europe, the Middle Ages or medieval period lasted approximately from the late 5th to the late 15th centuries, similar to the post-classical period of global history. It began with the fall of the Western Roman Empire a ...
: a mental confusion or continuous
delirium
Delirium (also known as acute confusional state) is an organically caused decline from a previous baseline of mental function that develops over a short period of time, typically hours to days. Delirium is a syndrome encompassing disturbances in ...
with
fever
Fever, also referred to as pyrexia, is defined as having a body temperature, temperature above the human body temperature, normal range due to an increase in the body's temperature Human body temperature#Fever, set point. There is not a single ...
.
Phrenitis means an
inflammation
Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving im ...
of the brain, or of the
meninges
In anatomy, the meninges (, ''singular:'' meninx ( or ), ) are the three membranes that envelop the brain and spinal cord. In mammals, the meninges are the dura mater, the arachnoid mater, and the pia mater. Cerebrospinal fluid is located in th ...
of the brain, attended with acute fever and delirium. Symptoms vary widely in severity, from short-lived, relatively slight effects of headache, drowsiness, and fever to
paralysis
Paralysis (also known as plegia) is a loss of motor function in one or more muscles. Paralysis can also be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage. In the United States, roughly 1 in 50 ...
,
coma
A coma is a deep state of prolonged unconsciousness in which a person cannot be awakened, fails to respond normally to painful stimuli, light, or sound, lacks a normal wake-sleep cycle and does not initiate voluntary actions. Coma patients exhi ...
, and
death
Death is the irreversible cessation of all biological functions that sustain an organism. For organisms with a brain, death can also be defined as the irreversible cessation of functioning of the whole brain, including brainstem, and brain ...
.
The ancient phrenitis concept was used until the 19th century. After that time the concept was replaced by the word delirium. By their epigonic character the detailed descriptions of phrenitis by
Gerard van Swieten
Gerard van Swieten (7 May 1700 – 18 June 1772) was a Dutch physician who from 1745 was the personal physician of the Holy Roman Empress Maria Theresa and transformed the Austrian health service and medical university education. He was the fa ...
mark only the end of an uncritical use of the term. The epoch-making work of
Morgagni, based on clinical-anatomical observations, provides a definitive insight into the location of the condition and into many pathologic features.
Pinel is the last author who mentions phrenitis in a classification of diseases.
Phrenitis is no longer in scientific use. Nowadays
meningitis
Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or ...
or
encephalitis
Encephalitis is inflammation of the brain. The severity can be variable with symptoms including reduction or alteration in consciousness, headache, fever, confusion, a stiff neck, and vomiting. Complications may include seizures, hallucinations, ...
are diagnosed. Relating to phrenitis: suffering from frenzy; delirious; mad; frantic; frenetic.
References
* {{cite journal , last1=Villarino Herrería , first1=H. , title=
hrenitis in Greco-Latin medicine, journal=Actas Luso-Espanolas De Neurologia, Psiquiatria Y Ciencias Afines , date=March 1997 , volume=25 , issue=2 , pages=128–134 , url=https://pubmed.ncbi.nlm.nih.gov/9245190/ , access-date=28 December 2021 , issn=0300-5062
Symptoms