Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
1-phosphatidyl-1
D-''myo''-inositol-3,4,5-trisphosphate 5-phosphohydrolase,
that has two isoforms: SHIP1 (produced by the gene
INPP5D
Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the ''INPP5D'' gene in humans. SHIP1 is expressed predominantly ...
) and SHIP2 (
INPPL1
SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the ''INPPL1'' gene.
INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase ...
).
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: 1-phosphatidyl-1
D-''myo''-inositol 3,4,5-trisphosphate + H
2O
1-phosphatidyl-1
D-''myo''-inositol 3,4-bisphosphate +
phosphate
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid .
The phosphate or orthophosphate ion is derived from phospho ...
This enzyme hydrolyses 1-phosphatidyl-1
D-''myo''-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P
3) to produce PtdIns(3,4)P
2.
References
External links
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EC 3.1.3